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A 28-year-old woman presents with a 3-month history of fatigue, weight gain of 8 kg, constipation, and cold intolerance. On examination, she has periorbital oedema, dry skin, and a heart rate of 52 bpm. Her reflexes show delayed relaxation.
Which investigation would be most useful to confirm the diagnosis?
Which investigation would be most useful to confirm the diagnosis?
is the key mechanism of action.
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This is a classic presentation of hypothyroidism with fatigue, weight gain, constipation, cold intolerance, bradycardia, dry skin, and delayed relaxation of reflexes. TSH will be elevated (in primary hypothyroidism) and free T4 will be low. Anti-TPO antibodies can help identify autoimmune (Hashimoto\'s) thyroiditis as the cause.
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