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Peri-arrest rhythms: bradycardia

Peri-arrest rhythms: bradycardia

The 2025 Resuscitation Council UK guidelines recommend that bradyarrhythmia is managed according to:
  • the presence of life-threatening features
  • the response to initial atropine
  • the subsequent risk of asystole

Initial assessment

Perform an ABCDE assessment:
  • give oxygen if appropriate
  • obtain IV access
  • monitor ECG, blood pressure and oxygen saturation
  • record a 12-lead ECG
  • identify and treat reversible causes, including electrolyte abnormalities

Assess for the following life-threatening features:
  • shock
  • syncope
  • myocardial ischaemia
  • severe heart failure
  • immediately following return of spontaneous circulation (ROSC)

Bradyarrhythmia with life-threatening features

Give atropine 500 micrograms IV and assess the response.

If the response is unsatisfactory, use the following interim measures:
  • repeat atropine 500 micrograms IV every 3–5 minutes, up to a maximum total dose of 3 mg
  • isoprenaline 5 micrograms/minute IV
  • adrenaline 2–10 micrograms/minute IV
  • consider alternative drugs:
    • aminophylline
    • dopamine
    • glucagon if beta-blocker or calcium-channel blocker overdose is suspected
    • glycopyrrolate may be used instead of atropine
  • and/or use transcutaneous pacing

Seek expert help. Continue monitoring, treat the underlying cause and consider transvenous pacing.

Important cautions:
  • do not give atropine to patients with a cardiac transplant, as it may cause high-grade AV block or sinus arrest; consider aminophylline
  • atropine is ineffective and may worsen high-grade AV block associated with a broad QRS complex


Risk of asystole

Assess the risk of asystole if:
  • there are no life-threatening features, or
  • there is a satisfactory response to atropine

The following are risk factors for asystole:
  • recent asystole
  • Mobitz type II AV block
  • complete heart block with a broad QRS complex
  • ventricular pause greater than 3 seconds

If there is a risk of asystole:
  • monitor the patient
  • identify and treat the underlying cause
  • consider transvenous pacing

If there are no life-threatening features and no risk of asystole, continue observation.
+PassMedicine Notes
The 2025 Resuscitation Council UK guidelines recommend that bradyarrhythmia is managed according to:
  • the presence of life-threatening features
  • the response to initial atropine
  • the subsequent risk of asystole

Initial assessment

Perform an ABCDE assessment:
  • give oxygen if appropriate
  • obtain IV access
  • monitor ECG, blood pressure and oxygen saturation
  • record a 12-lead ECG
  • identify and treat reversible causes, including electrolyte abnormalities
Assess for the following life-threatening features:
  • shock
  • syncope
  • myocardial ischaemia
  • severe heart failure
  • immediately following return of spontaneous circulation (ROSC)

Bradyarrhythmia with life-threatening features

Give atropine 500 micrograms IV and assess the response.

If the response is unsatisfactory, use the following interim measures:
  • repeat atropine 500 micrograms IV every 3–5 minutes, up to a maximum total dose of 3 mg
  • isoprenaline 5 micrograms/minute IV
  • adrenaline 2–10 micrograms/minute IV
  • consider alternative drugs:
    • aminophylline
    • dopamine
    • glucagon if beta-blocker or calcium-channel blocker overdose is suspected
    • glycopyrrolate may be used instead of atropine
  • and/or use transcutaneous pacing

Seek expert help. Continue monitoring, treat the underlying cause and consider transvenous pacing.

Important cautions:
  • do not give atropine to patients with a cardiac transplant, as it may cause high-grade AV block or sinus arrest; consider aminophylline
  • atropine is ineffective and may worsen high-grade AV block associated with a broad QRS complex

Risk of asystole

Assess the risk of asystole if:
  • there are no life-threatening features, or
  • there is a satisfactory response to atropine
The following are risk factors for asystole:
  • recent asystole
  • Mobitz type II AV block
  • complete heart block with a broad QRS complex
  • ventricular pause greater than 3 seconds
If there is a risk of asystole:
  • monitor the patient
  • identify and treat the underlying cause
  • consider transvenous pacing

If there are no life-threatening features and no risk of asystole, continue observation.



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