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ALL / Cardiology
Peri-arrest rhythms: bradycardia
Peri-arrest rhythms: bradycardia
The 2025 Resuscitation Council UK guidelines recommend that bradyarrhythmia is managed according to:- the presence of life-threatening features
- the response to initial atropine
- the subsequent risk of asystole
Initial assessment
Perform an ABCDE assessment:
- give oxygen if appropriate
- obtain IV access
- monitor ECG, blood pressure and oxygen saturation
- record a 12-lead ECG
- identify and treat reversible causes, including electrolyte abnormalities
Assess for the following life-threatening features:
- shock
- syncope
- myocardial ischaemia
- severe heart failure
- immediately following return of spontaneous circulation (ROSC)
Bradyarrhythmia with life-threatening features
Give atropine 500 micrograms IV and assess the response.
If the response is unsatisfactory, use the following interim measures:
- repeat atropine 500 micrograms IV every 3–5 minutes, up to a maximum total dose of 3 mg
- isoprenaline 5 micrograms/minute IV
- adrenaline 2–10 micrograms/minute IV
- consider alternative drugs:
- aminophylline
- dopamine
- glucagon if beta-blocker or calcium-channel blocker overdose is suspected
- glycopyrrolate may be used instead of atropine
- and/or use transcutaneous pacing
Seek expert help. Continue monitoring, treat the underlying cause and consider transvenous pacing.
Important cautions:
- do not give atropine to patients with a cardiac transplant, as it may cause high-grade AV block or sinus arrest; consider aminophylline
- atropine is ineffective and may worsen high-grade AV block associated with a broad QRS complex
Risk of asystole
Assess the risk of asystole if:
- there are no life-threatening features, or
- there is a satisfactory response to atropine
The following are risk factors for asystole:
- recent asystole
- Mobitz type II AV block
- complete heart block with a broad QRS complex
- ventricular pause greater than 3 seconds
If there is a risk of asystole:
- monitor the patient
- identify and treat the underlying cause
- consider transvenous pacing
If there are no life-threatening features and no risk of asystole, continue observation.
+PassMedicine Notes
The 2025 Resuscitation Council UK guidelines recommend that bradyarrhythmia is managed according to:
- the presence of life-threatening features
- the response to initial atropine
- the subsequent risk of asystole
Initial assessment
Perform an ABCDE assessment:- give oxygen if appropriate
- obtain IV access
- monitor ECG, blood pressure and oxygen saturation
- record a 12-lead ECG
- identify and treat reversible causes, including electrolyte abnormalities
- shock
- syncope
- myocardial ischaemia
- severe heart failure
- immediately following return of spontaneous circulation (ROSC)
Bradyarrhythmia with life-threatening features
Give atropine 500 micrograms IV and assess the response.
If the response is unsatisfactory, use the following interim measures:- repeat atropine 500 micrograms IV every 3–5 minutes, up to a maximum total dose of 3 mg
- isoprenaline 5 micrograms/minute IV
- adrenaline 2–10 micrograms/minute IV
- consider alternative drugs:
- aminophylline
- dopamine
- glucagon if beta-blocker or calcium-channel blocker overdose is suspected
- glycopyrrolate may be used instead of atropine
- and/or use transcutaneous pacing
Seek expert help. Continue monitoring, treat the underlying cause and consider transvenous pacing.
Important cautions:- do not give atropine to patients with a cardiac transplant, as it may cause high-grade AV block or sinus arrest; consider aminophylline
- atropine is ineffective and may worsen high-grade AV block associated with a broad QRS complex
Risk of asystole
Assess the risk of asystole if:- there are no life-threatening features, or
- there is a satisfactory response to atropine
- recent asystole
- Mobitz type II AV block
- complete heart block with a broad QRS complex
- ventricular pause greater than 3 seconds
- monitor the patient
- identify and treat the underlying cause
- consider transvenous pacing
If there are no life-threatening features and no risk of asystole, continue observation.

