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ALL / Nephrology

Plasma exchange

Plasma exchange

Indications for plasma exchange (also known as plasmapheresis)
  • Guillain-Barre syndrome
  • myasthenia gravis
  • Goodpasture's syndrome
  • ANCA positive vasculitis if rapidly progressive renal failure or pulmonary haemorrhage
  • TTP/HUS
  • cryoglobulinaemia
  • hyperviscosity syndrome e.g. secondary to myeloma

Complications of plasma exchange
  • hypocalcaemia: due to the presence of citrate used as an anticoagulant for the extracorporeal system
  • metabolic alkalosis
  • removal of systemic medications
  • coagulation factor depletion
  • immunoglobulin depletion
+PassMedicine Notes
Indications for plasma exchange (also known as plasmapheresis)
  • Guillain-Barre syndrome
  • myasthenia gravis
  • Goodpasture's syndrome
  • ANCA positive vasculitis if rapidly progressive renal failure or pulmonary haemorrhage
  • TTP/HUS
  • cryoglobulinaemia
  • hyperviscosity syndrome e.g. secondary to myeloma
Complications of plasma exchange
  • hypocalcaemia: due to the presence of citrate used as an anticoagulant for the extracorporeal system
  • metabolic alkalosis
  • removal of systemic medications
  • coagulation factor depletion
  • immunoglobulin depletion


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