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ALL / Pharmacology
Acute intermittent porphyria: drugs
Acute intermittent porphyria: drugs
Acute intermittent porphyria (AIP) is an autosomal dominant condition caused by a defect in porphobilinogen deaminase, an enzyme involved in the biosynthesis of haem. It characteristically presents with abdominal and neuropsychiatric symptoms in 20-40 year olds. AIP is more common in females (5:1)Drugs which may precipitate attack
- barbiturates
- halothane
- benzodiazepines
- alcohol
- oral contraceptive pill
- sulphonamides
Drugs considered safe to use
- paracetamol
- aspirin
- codeine
- morphine
- chlorpromazine
- beta-blockers
- penicillin
- metformin
+PassMedicine Notes
Acute intermittent porphyria (AIP) is an autosomal dominant condition caused by a defect in porphobilinogen deaminase, an enzyme involved in the biosynthesis of haem. It characteristically presents with abdominal and neuropsychiatric symptoms in 20-40 year olds. AIP is more common in females (5:1)
Drugs which may precipitate attack- barbiturates
- halothane
- benzodiazepines
- alcohol
- oral contraceptive pill
- sulphonamides
- paracetamol
- aspirin
- codeine
- morphine
- chlorpromazine
- beta-blockers
- penicillin
- metformin
