Antibiotics: protein synthesis inhibitors

Drug_Mechanism of action_Adverse effects _Notes| Aminoglycosides _ Binds to 30S subunit causing misreading of mRNA _ Nephrotoxicity, Ototoxicity _ | Tetracyclines _ Binds to 30S subunit blocking binding of aminoacyl-tRNA _ Discolouration of teeth, photosensitivity _ | Chloramphenicol _Binds to 50S subunit, inhibiting peptidyl transferase _ Aplastic anaemia _| Clindamycin _ Binds to 50S subunit, inhibiting translocation (movement of tRNA from acceptor site to peptidyl site) _ Common cause of C. difficile diarrhoea _ | Macrolides _ Binds to 50S subunit, inhibiting translocation (movement of tRNA from acceptor site to peptidyl site) _ Nausea (especially erythromycin), P450 inhibitor, prolonged QT interval_ Commonly used for patients who are allergic to penicillin|