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Sickle-cell anaemia: management

Sickle-cell anaemia: management

Crisis management
  • analgesia e.g. opiates
  • rehydrate
  • oxygen
  • consider antibiotics if evidence of infection
  • blood transfusion
  • exchange transfusion: e.g. if neurological complications

Longer-term management
  • hydroxyurea
    • increases the HbF levels and is used in the prophylactic management of sickle cell anaemia to prevent painful episodes
  • sickle cell patients should receive the pneumococcal polysaccharide vaccine every 5 years
+PassMedicine Notes
Crisis management
  • analgesia e.g. opiates
  • rehydrate
  • oxygen
  • consider antibiotics if evidence of infection
  • blood transfusion
  • exchange transfusion: e.g. if neurological complications
Longer-term management
  • hydroxyurea
    • increases the HbF levels and is used in the prophylactic management of sickle cell anaemia to prevent painful episodes
  • sickle cell patients should receive the pneumococcal polysaccharide vaccine every 5 years


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