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ALL / Clinical Sciences
Cell cycle
Cell cycle
The cell cycle is regulated by proteins called cyclins which in turn control cyclin-dependent kinase (CDK) enzymes.| Phase | Notes | Regulatory proteins |
|---|---|---|
| G0 |
| |
| G1 |
| Cyclin D / CDK4, Cyclin D / CDK6 and Cyclin E / CDK2: regulates transition from G1 to S phase |
| S |
| Cyclin A / CDK2: active in S phase |
| G2 |
| Cyclin B / CDK1: regulates transition from G2 to M phase |
| M |
|
+PassMedicine Notes
The cell cycle is regulated by proteins called cyclins which in turn control cyclin-dependent kinase (CDK) enzymes.
Phase _ Notes _ Regulatory proteins| G0 _- 'resting' phase
- quiescent cells such as hepatocytes and more permanently resting cells such as neurons _ |
- Gap 1, cells increase in size
- determines length of cell cycle
- under influence of p53_ Cyclin D / CDK4, Cyclin D / CDK6 and Cyclin E / CDK2: regulates transition from G1 to S phase|
- Synthesis of DNA, RNA and histone
- centrosome duplication _ Cyclin A / CDK2: active in S phase |
- Gap 2, cells continue to increase in size _ Cyclin B / CDK1: regulates transition from G2 to M phase|
- Mitosis - cell division
- the shortest phase of the cell cycle _ |
