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Brain lesions

Brain lesions

The following neurological disorders/features may allow localisation of a brain lesion:

Gross anatomy

Parietal lobe lesions
  • sensory inattention
  • apraxias
  • astereognosis (tactile agnosia)
  • inferior homonymous quadrantanopia
  • Gerstmann's syndrome (lesion of dominant parietal): alexia, acalculia, finger agnosia and right-left disorientation

Occipital lobe lesions
  • homonymous hemianopia (with macula sparing)
  • cortical blindness
  • visual agnosia

Temporal lobe lesion
  • Wernicke's aphasia: this area 'forms' the speech before 'sending it' to Brocas area. Lesions result in word substituion, neologisms but speech remains fluent
  • superior homonymous quadrantanopia
  • auditory agnosia
  • prosopagnosia (difficulty recognising faces)

Frontal lobes lesions
  • expressive (Broca's) aphasia: located on the posterior aspect of the frontal lobe, in the inferior frontal gyrus. Speech is non-fluent, laboured, and halting
  • disinhibition
  • perseveration
  • anosmia
  • inability to generate a list

Cerebellum lesions
  • midline lesions: gait and truncal ataxia
  • hemisphere lesions: intention tremor, past pointing, dysdiadokinesis, nystagmus

More specific areas

AreaAssociated conditions
Medial thalamus and mammillary bodies of the hypothalamusWernicke and Korsakoff syndrome
Subthalamic nucleus of the basal gangliaHemiballism
Striatum (caudate nucleus) of the basal gangliaHuntington chorea
Substantia nigra of the basal gangliaParkinson's disease
AmygdalaKluver-Bucy syndrome (hypersexuality, hyperorality, hyperphagia, visual agnosia
+PassMedicine Notes

The following neurological disorders/features may allow localisation of a brain lesion:

Gross anatomy

Parietal lobe lesions
  • sensory inattention
  • apraxias
  • astereognosis (tactile agnosia)
  • inferior homonymous quadrantanopia
  • Gerstmann's syndrome (lesion of dominant parietal): alexia, acalculia, finger agnosia and right-left disorientation
Occipital lobe lesions
  • homonymous hemianopia (with macula sparing)
  • cortical blindness
  • visual agnosia
Temporal lobe lesion
  • Wernicke's aphasia: this area 'forms' the speech before 'sending it' to Brocas area. Lesions result in word substituion, neologisms but speech remains fluent
  • superior homonymous quadrantanopia
  • auditory agnosia
  • prosopagnosia (difficulty recognising faces)
Frontal lobes lesions
  • expressive (Broca's) aphasia: located on the posterior aspect of the frontal lobe, in the inferior frontal gyrus. Speech is non-fluent, laboured, and halting
  • disinhibition
  • perseveration
  • anosmia
  • inability to generate a list
Cerebellum lesions
  • midline lesions: gait and truncal ataxia
  • hemisphere lesions: intention tremor, past pointing, dysdiadokinesis, nystagmus

More specific areas

Area _ Associated conditions| Medial thalamus and mammillary bodies of the hypothalamus_ Wernicke and Korsakoff syndrome| Subthalamic nucleus of the basal ganglia _ Hemiballism| Striatum (caudate nucleus) of the basal ganglia _ Huntington chorea| Substantia nigra of the basal ganglia _ Parkinson's disease| Amygdala _ Kluver-Bucy syndrome (hypersexuality, hyperorality, hyperphagia, visual agnosia|

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Klüver-Bucy syndrome
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Klüver-Bucy syndrome
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