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ALL / Neurology

Levodopa

Levodopa

Overview
  • usually combined with a decarboxylase inhibitor (e.g. carbidopa or benserazide) to prevent peripheral metabolism of L-dopa to dopamine
  • reduced effectiveness with time (usually by 2 years)
  • no use in neuroleptic induced parkinsonism

Adverse effects
  • dyskinesia
  • 'on-off' effect
  • postural hypotension
  • cardiac arrhythmias
  • nausea & vomiting
  • psychosis
  • reddish discolouration of urine upon standing
+PassMedicine Notes
Overview
  • usually combined with a decarboxylase inhibitor (e.g. carbidopa or benserazide) to prevent peripheral metabolism of L-dopa to dopamine
  • reduced effectiveness with time (usually by 2 years)
  • no use in neuroleptic induced parkinsonism
Adverse effects
  • dyskinesia
  • 'on-off' effect
  • postural hypotension
  • cardiac arrhythmias
  • nausea & vomiting
  • psychosis
  • reddish discolouration of urine upon standing


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