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ALL / Rheumatology
Drug-induced lupus
Drug-induced lupus
In drug-induced lupus not all the typical features of systemic lupus erythematosus are seen, with renal and nervous system involvement being unusual. It usually resolves on stopping the drug.Features
- arthralgia
- myalgia
- skin (e.g. malar rash) and pulmonary involvement (e.g. pleurisy) are common
- ANA positive in 100%, dsDNA negative
- anti-histone antibodies are found in 80-90%
- anti-Ro, anti-Smith positive in around 5%
A woman with drug-induced lupus
Most common causes
- procainamide
- hydralazine
Less common causes
- isoniazid
- minocycline
- phenytoin
+PassMedicine Notes
In drug-induced lupus not all the typical features of systemic lupus erythematosus are seen, with renal and nervous system involvement being unusual. It usually resolves on stopping the drug.
Features- arthralgia
- myalgia
- skin (e.g. malar rash) and pulmonary involvement (e.g. pleurisy) are common
- ANA positive in 100%, dsDNA negative
- anti-histone antibodies are found in 80-90%
- anti-Ro, anti-Smith positive in around 5%
- procainamide
- hydralazine
- isoniazid
- minocycline
- phenytoin