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ALL / Haematology
Hairy cell leukaemia
Hairy cell leukaemia
Hairy cell leukaemia is a rare malignant proliferation disorder of B cells. It is more common in males (4:1)Features
- pancytopenia
- splenomegaly
- skin vasculitis in 1/3 patients
- 'dry tap' despite bone marrow hypercellularity
- tartrate resistant acid phosphotase (TRAP) stain positive
Management
- chemotherapy is first-line: cladribine, pentostatin
- immunotherapy is second-line: rituximab, interferon-alpha
+PassMedicine Notes
Hairy cell leukaemia is a rare malignant proliferation disorder of B cells. It is more common in males (4:1)
Features- pancytopenia
- splenomegaly
- skin vasculitis in 1/3 patients
- 'dry tap' despite bone marrow hypercellularity
- tartrate resistant acid phosphotase (TRAP) stain positive
- chemotherapy is first-line: cladribine, pentostatin
- immunotherapy is second-line: rituximab, interferon-alpha