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ALL / Infectious Diseases
Tetracyclines
Tetracyclines
Tetracyclines are a class of antibiotics which are commonly used in clinical practice.Examples
- doxycycline
- tetracycline
Mechanism of action
- protein synthesis inhibitors
- binds to 30S subunit blocking binding of aminoacyl-tRNA
Mechanism of resistance
- increased efflux of the bacteria by plasmid-encoded transport pumps, ribosomal protection
Indications
- acne vulgaris
- Lyme disease
- Chlamydia
- Mycoplasma pneumoniae
Notable adverse effects
- discolouration of teeth: therefore should not be used in children < 12 years of age
- photosensitivity
- angioedema
- black hairy tongue
Tetracyclines should not be given to women who are pregnant or breastfeeding due to the risk of discolouration of the infant's teeth.
+PassMedicine Notes
Tetracyclines are a class of antibiotics which are commonly used in clinical practice.
Examples- doxycycline
- tetracycline
- protein synthesis inhibitors
- binds to 30S subunit blocking binding of aminoacyl-tRNA
- increased efflux of the bacteria by plasmid-encoded transport pumps, ribosomal protection
- acne vulgaris
- Lyme disease
- Chlamydia
- Mycoplasma pneumoniae
- discolouration of teeth: therefore should not be used in children < 12 years of age
- photosensitivity
- angioedema
- black hairy tongue
Tetracyclines should not be given to women who are pregnant or breastfeeding due to the risk of discolouration of the infant's teeth.