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ALL / Pharmacology
Finasteride
Finasteride
Finasteride is an inhibitor of 5 alpha-reductase, an enzyme which metabolises testosterone into dihydrotestosterone.Indications
- benign prostatic hyperplasia
- indicated if the patient has a significantly enlarged prostate and is considered to be at high risk of progression
- unlike alpha-1 antagonists causes a reduction in prostate volume and hence may slow disease progression. This however takes time and symptoms may not improve for 6 months
- male-pattern baldness
Adverse effects
- impotence
- decrease libido
- ejaculation disorders
- gynaecomastia and breast tenderness
Finasteride causes decreased levels of serum prostate-specific antigen
+PassMedicine Notes
Finasteride is an inhibitor of 5 alpha-reductase, an enzyme which metabolises testosterone into dihydrotestosterone.
Indications- benign prostatic hyperplasia
- indicated if the patient has a significantly enlarged prostate and is considered to be at high risk of progression
- unlike alpha-1 antagonists causes a reduction in prostate volume and hence may slow disease progression. This however takes time and symptoms may not improve for 6 months
- male-pattern baldness
- impotence
- decrease libido
- ejaculation disorders
- gynaecomastia and breast tenderness
Finasteride causes decreased levels of serum prostate-specific antigen