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ALL / Clinical Sciences

Leukotrienes

Leukotrienes

Function
  • mediators of inflammation and allergic reactions
  • cause bronchoconstriction, mucous production
  • increase vascular permeability, attract leukocytes
  • leukotriene D4 has been identified as the SRS-A (slow reacting substance of anaphylaxis)

Production
  • secreted by leukocytes
  • formed from arachidonic acid by action of lipoxygenase
  • it is thought that the NSAID induced bronchospasm in asthmatics is secondary to the express production of leukotrienes due to the inhibition of prostaglandin synthetase
+PassMedicine Notes
Function
  • mediators of inflammation and allergic reactions
  • cause bronchoconstriction, mucous production
  • increase vascular permeability, attract leukocytes
  • leukotriene D4 has been identified as the SRS-A (slow reacting substance of anaphylaxis)
Production
  • secreted by leukocytes
  • formed from arachidonic acid by action of lipoxygenase
  • it is thought that the NSAID induced bronchospasm in asthmatics is secondary to the express production of leukotrienes due to the inhibition of prostaglandin synthetase


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