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ALL / Endocrinology
Carbimazole
Carbimazole
Carbimazole is used in the management of thyrotoxicosis. It is typically given in high doses for 6 weeks until the patient becomes euthyroid before being reduced.Mechanism of action
- blocks thyroid peroxidase from coupling and iodinating the tyrosine residues on thyroglobulin → reducing thyroid hormone production
- in contrast propylthiouracil as well as this central mechanism of action also has a peripheral action by inhibiting 5'-deiodinase which reduces peripheral conversion of T4 to T3
Adverse effects
- agranulocytosis
- crosses the placenta, but may be used in low doses during pregnancy
+PassMedicine Notes
Carbimazole is used in the management of thyrotoxicosis. It is typically given in high doses for 6 weeks until the patient becomes euthyroid before being reduced.
Mechanism of action- blocks thyroid peroxidase from coupling and iodinating the tyrosine residues on thyroglobulin --> reducing thyroid hormone production
- in contrast propylthiouracil as well as this central mechanism of action also has a peripheral action by inhibiting 5'-deiodinase which reduces peripheral conversion of T4 to T3
- agranulocytosis
- crosses the placenta, but may be used in low doses during pregnancy
