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ALL / Infectious Diseases
Vancomycin
Vancomycin
Vancomycin is a glycopeptide antibiotic used in the treatment of Gram-positive infections, particularly methicillin-resistant Staphylococcus aureus (MRSA).Mechanism of action
- inhibits cell wall formation by binding to D-Ala-D-Ala moieties, preventing polymerization of peptidoglycans
Mechanism of resistance
- alteration to the terminal amino acid residues of the NAM/NAG-peptide subunits (normally D-alanyl-D-alanine) to which the antibiotic binds
Adverse effects
- nephrotoxicity
- ototoxicity
- thrombophlebitis
- red man syndrome; occurs on rapid infusion of vancomycin
+PassMedicine Notes
Vancomycin is a glycopeptide antibiotic used in the treatment of Gram-positive infections, particularly methicillin-resistant Staphylococcus aureus (MRSA).
Mechanism of action- inhibits cell wall formation by binding to D-Ala-D-Ala moieties, preventing polymerization of peptidoglycans
- alteration to the terminal amino acid residues of the NAM/NAG-peptide subunits (normally D-alanyl-D-alanine) to which the antibiotic binds
- nephrotoxicity
- ototoxicity
- thrombophlebitis
- red man syndrome; occurs on rapid infusion of vancomycin