Protein C deficiency

Protein C deficiency is an autosomal codominant condition which causes an increased risk of thrombosis

• venous thromboembolism
• skin necrosis following the commencement of warfarin: when warfarin is first started biosynthesis of protein C is reduced. This results in a temporary procoagulant state after initially starting warfarin, normally avoided by concurrent heparin administration. Thrombosis may occur in venules leading to skin necrosis