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Rifampicin

Rifampicin

Rifampicin is an antibiotic which is used to treat a variety of infections. It is frequently used to treat tuberculosis (in combination with other medications).

Rifampicin can also be used for prophylaxis in those who have had close contact with tuberculosis or meningitis.

Mechanism of action
  • inhibits bacterial DNA dependent RNA polymerase preventing transcription of DNA into mRNA

Adverse effects
  • potent CYP450 liver enzyme inducer
  • hepatitis
  • orange secretions
  • flu-like symptoms
+PassMedicine Notes

Rifampicin is an antibiotic which is used to treat a variety of infections. It is frequently used to treat tuberculosis (in combination with other medications).

Rifampicin can also be used for prophylaxis in those who have had close contact with tuberculosis or meningitis.

Mechanism of action
  • inhibits bacterial DNA dependent RNA polymerase preventing transcription of DNA into mRNA
Adverse effects
  • potent CYP450 liver enzyme inducer
  • hepatitis
  • orange secretions
  • flu-like symptoms


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