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ALL / Gastroenterology
Cholestyramine
Cholestyramine
Cholestyramine is a bile acid sequestrant used in the management of hyperlipidaemia. It decreases bile acid reabsorption in the small intestine, therefore upregulating the amount of cholesterol that is converted to bile acid. The main effect it has on the lipid profile is to reduce LDL cholesterol. It is also occasionally used in Crohn's disease for treatment diarrhoea following bowel resection.Adverse effects
- abdominal cramps and constipation
- decreases absorption of fat-soluble vitamins
- cholesterol gallstones
- may raise level of triglycerides
+PassMedicine Notes
Cholestyramine is a bile acid sequestrant used in the management of hyperlipidaemia. It
decreases bile acid reabsorption in the small intestine, therefore upregulating the amount of cholesterol that is converted to bile acid. The main effect it has on the lipid profile is to reduce LDL cholesterol. It is also occasionally used in Crohn's disease for treatment diarrhoea following bowel resection.
Adverse effects
- abdominal cramps and constipation
- decreases absorption of fat-soluble vitamins
- cholesterol gallstones
- may raise level of triglycerides