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ALL / Gastroenterology

Proton pump inhibitors

Proton pump inhibitors

Proton pump inhibitors (PPI) cause irreversible blockade of H+/K+ ATPase of the gastric parietal cell.

Examples include omeprazole and lansoprazole.

Adverse effects
  • hyponatraemia, hypomagnasaemia
  • osteoporosis → increased risk of fractures
  • microscopic colitis
  • increased risk of C. difficile infections
+PassMedicine Notes

Proton pump inhibitors (PPI) cause irreversible blockade of H+/K+ ATPase of the gastric parietal cell.

Examples include omeprazole and lansoprazole.

Adverse effects
  • hyponatraemia, hypomagnasaemia
  • osteoporosis --> increased risk of fractures
  • microscopic colitis
  • increased risk of C. difficile infections


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