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ALL / Clinical Sciences
Endothelin
Endothelin
Endothelin is a potent, long-acting vasoconstrictor and bronchoconstrictor. It is secreted initially as a prohormone by the vascular endothelium and later converted to ET-1 by the action of endothelin converting enzyme. It acts via interaction with a G-protein linked to phospholipase C leading to calcium release. Endothelin is thought to be important in the pathogenesis of many diseases including primary pulmonary hypertension (endothelin antagonists are now used), cardiac failure, hepatorenal syndrome and Raynaud's.Promotes release
- angiotensin II
- ADH
- hypoxia
- mechanical shearing forces
Inhibits release
- nitric oxide
- prostacyclin
Raised levels in
- primary pulmonary hypertension
- myocardial infarction
- heart failure
- acute kidney injury
- asthma
+PassMedicine Notes
Endothelin is a potent, long-acting vasoconstrictor and bronchoconstrictor. It is secreted initially as a prohormone by the vascular endothelium and later converted to ET-1 by the action of endothelin converting enzyme. It acts via interaction with a G-protein linked to phospholipase C leading to calcium release. Endothelin is thought to be important in the pathogenesis of many diseases including primary pulmonary hypertension (endothelin antagonists are now used), cardiac failure, hepatorenal syndrome and Raynaud's.
Promotes release- angiotensin II
- ADH
- hypoxia
- mechanical shearing forces
- nitric oxide
- prostacyclin
- primary pulmonary hypertension
- myocardial infarction
- heart failure
- acute kidney injury
- asthma