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ALL / Neurology

Peripheral neuropathy

Peripheral neuropathy

Peripheral neuropathy may be divided into conditions which predominately cause a motor or sensory loss

Predominately motor loss
  • Guillain-Barre syndrome
  • porphyria
  • lead poisoning
  • hereditary sensorimotor neuropathies (HSMN) - Charcot-Marie-Tooth
  • chronic inflammatory demyelinating polyneuropathy (CIDP)
  • diphtheria

Predominately sensory loss
  • diabetes
  • uraemia
  • leprosy
  • alcoholism
  • vitamin B12 deficiency
  • amyloidosis

Alcoholic neuropathy
  • secondary to both direct toxic effects and reduced absorption of B vitamins
  • sensory symptoms typically present prior to motor symptoms

Vitamin B12 deficiency
  • subacute combined degeneration of spinal cord
  • dorsal column usually affected first (joint position, vibration) prior to distal paraesthesia
+PassMedicine Notes

Peripheral neuropathy may be divided into conditions which predominately cause a motor or sensory loss

Predominately motor loss
  • Guillain-Barre syndrome
  • porphyria
  • lead poisoning
  • hereditary sensorimotor neuropathies (HSMN) - Charcot-Marie-Tooth
  • chronic inflammatory demyelinating polyneuropathy (CIDP)
  • diphtheria
Predominately sensory loss
  • diabetes
  • uraemia
  • leprosy
  • alcoholism
  • vitamin B12 deficiency
  • amyloidosis
Alcoholic neuropathy
  • secondary to both direct toxic effects and reduced absorption of B vitamins
  • sensory symptoms typically present prior to motor symptoms
Vitamin B12 deficiency
  • subacute combined degeneration of spinal cord
  • dorsal column usually affected first (joint position, vibration) prior to distal paraesthesia


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