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ALL / Haematology
Tumour markers
Tumour markers
Tumour markers may be divided into:- monoclonal antibodies against carbohydrate or glycoprotein tumour antigens
- tumour antigens
- enzymes (alkaline phosphatase, neurone specific enolase)
- hormones (e.g. calcitonin, ADH)
It should be noted that tumour markers usually have a low specificity
Monoclonal antibodies
| Tumour marker | Association |
|---|---|
| CA 125 | Ovarian cancer |
| CA 19-9 | Pancreatic cancer |
| CA 15-3 | Breast cancer |
Tumour antigens
| Tumour marker | Association |
|---|---|
| Prostate specific antigen (PSA) | Prostatic carcinoma |
| Alpha-feto protein (AFP) | Hepatocellular carcinoma, teratoma |
| Carcinoembryonic antigen (CEA) | Colorectal cancer |
| S-100 | Melanoma, schwannomas |
| Bombesin | Small cell lung carcinoma, gastric cancer, neuroblastoma |
+PassMedicine Notes
Tumour markers may be divided into:
- monoclonal antibodies against carbohydrate or glycoprotein tumour antigens
- tumour antigens
- enzymes (alkaline phosphatase, neurone specific enolase)
- hormones (e.g. calcitonin, ADH)
It should be noted that tumour markers usually have a low specificity