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ALL / Cardiology
Adrenaline
Adrenaline
Adrenaline is a sympathomimetic amine with both alpha and beta adrenergic stimulating propertiesIndications
- anaphylaxis
- cardiac arrest
Recommend Adult Life Support (ALS) adrenaline doses
- anaphylaxis: 0.5ml 1:1,000 IM
- cardiac arrest: 10ml 1:10,000 IV or 1ml of 1:1000 IV
Management of accidental injection e.g. resulting in digital ischaemia
- local infiltration of phentolamine
Background
- responsible for the fight or flight response
- released by the adrenal glands
- acts on α 1 and 2, β 1 and 2 receptors
- acts on β 2 receptors in skeletal muscle vessels-causing vasodilation
- increases cardiac output and total peripheral resistance
- causes vasoconstriction in the skin and kidneys causing a narrow pulse pressure
Actions on α adrenergic receptors:
- inhibits insulin secretion by the pancreas
- stimulates glycogenolysis in the liver and muscle
- stimulates glycolysis in muscle
Actions onβ adrenergic receptors:
- stimulates glucagon secretion in the pancreas
- stimulates ACTH
- stimulates lipolysis by adipose tissue
+PassMedicine Notes
Adrenaline is a sympathomimetic amine with both alpha and beta adrenergic stimulating properties
Indications- anaphylaxis
- cardiac arrest
- anaphylaxis: 0.5ml 1:1,000 IM
- cardiac arrest: 10ml 1:10,000 IV or 1ml of 1:1000 IV
- local infiltration of phentolamine
- responsible for the fight or flight response
- released by the adrenal glands
- acts on #alpha# 1 and 2, #beta# 1 and 2 receptors
- acts on #beta# 2 receptors in skeletal muscle vessels-causing vasodilation
- increases cardiac output and total peripheral resistance
- causes vasoconstriction in the skin and kidneys causing a narrow pulse pressure
- inhibits insulin secretion by the pancreas
- stimulates glycogenolysis in the liver and muscle
- stimulates glycolysis in muscle
- stimulates glucagon secretion in the pancreas
- stimulates ACTH
- stimulates lipolysis by adipose tissue