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ALL / Pharmacology

Adrenoceptors

Adrenoceptors

Alpha-1
  • vasoconstriction
  • relaxation of GI smooth muscle
  • salivary secretion
  • hepatic glycogenolysis

Alpha-2
  • mainly presynaptic: inhibition of transmitter release (inc NA, Ach from autonomic nerves)
  • inhibits insulin
  • platelet aggregation

Beta-1
  • mainly located in the heart
  • increase heart rate + force

Beta-2
  • vasodilation
  • bronchodilation
  • relaxation of GI smooth muscle

Beta-3
  • lipolysis

Adrenoceptors

Pathways
  • all are G-protein coupled
  • alpha-1:activate phospholipase C → IP3 → DAG
  • alpha-2: inhibit adenylate cyclase
  • beta-1: stimulate adenylate cyclase
  • beta-2: stimulate adenylate cyclase
  • beta-3: stimulate adenylate cyclase
+PassMedicine Notes
Alpha-1
  • vasoconstriction
  • relaxation of GI smooth muscle
  • salivary secretion
  • hepatic glycogenolysis
Alpha-2
  • mainly presynaptic: inhibition of transmitter release (inc NA, Ach from autonomic nerves)
  • inhibits insulin
  • platelet aggregation
Beta-1
  • mainly located in the heart
  • increase heart rate + force
Beta-2
  • vasodilation
  • bronchodilation
  • relaxation of GI smooth muscle
Beta-3
  • lipolysis
Pathways
  • all are G-protein coupled
  • alpha-1:activate phospholipase C --> IP3 --> DAG
  • alpha-2: inhibit adenylate cyclase
  • beta-1: stimulate adenylate cyclase
  • beta-2: stimulate adenylate cyclase
  • beta-3: stimulate adenylate cyclase


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