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ALL / Cardiology
Hypertrophic obstructive cardiomyopathy: prognostic factors
Hypertrophic obstructive cardiomyopathy: prognostic factors
Hypertrophic obstructive cardiomyopathy (HOCM) is an autosomal dominant disorder of muscle tissue caused by defects in the genes encoding contractile proteins. Mutations to various proteins including beta-myosin, alpha-tropomyosin and troponin T have been identified. Septal hypertrophy causes left ventricular outflow obstruction. It is an important cause of sudden death in apparently healthy individuals.Poor prognostic factors
- increased septal wall thickness > 3cm
- syncope
- family history of sudden death
- young age at presentation
- non-sustained ventricular tachycardia on 24 or 48-hour Holter monitoring
- abnormal blood pressure changes on exercise
Genetics and pathophysiology in HOCM
+PassMedicine Notes
Hypertrophic obstructive cardiomyopathy (HOCM) is an autosomal dominant disorder of muscle tissue caused by defects in the genes encoding contractile proteins. Mutations to various proteins including beta-myosin, alpha-tropomyosin and troponin T have been identified. Septal hypertrophy causes left ventricular outflow obstruction. It is an important cause of sudden death in apparently healthy individuals.
Poor prognostic factors- increased septal wall thickness > 3cm
- syncope
- family history of sudden death
- young age at presentation
- non-sustained ventricular tachycardia on 24 or 48-hour Holter monitoring
- abnormal blood pressure changes on exercise
