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ALL / Haematology
Cyclophosphamide
Cyclophosphamide
Cyclophosphamide is an alkylating agent used in the management of cancer and autoimmune conditions. It works by causing cross-linking of DNAAdverse effects
- haemorrhagic cystitis: incidence reduced by the use of hydration and mesna
- myelosuppression
- transitional cell carcinoma
Mesna
- 2-mercaptoethane sulfonate Na
- a metabolite of cyclophosphamide called acrolein is toxic to urothelium
- mesna binds to and inactivates acrolein helping to prevent haemorrhagic cystitis
+PassMedicine Notes
Cyclophosphamide is an alkylating agent used in the management of cancer and autoimmune conditions. It works by causing cross-linking of DNA
Adverse effects- haemorrhagic cystitis: incidence reduced by the use of hydration and mesna
- myelosuppression
- transitional cell carcinoma
- 2-mercaptoethane sulfonate Na
- a metabolite of cyclophosphamide called acrolein is toxic to urothelium
- mesna binds to and inactivates acrolein helping to prevent haemorrhagic cystitis
