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ALL / Rheumatology

Rheumatoid arthritis: prognostic features

Rheumatoid arthritis: prognostic features

A number of features have been shown to predict a poor prognosis in patients with rheumatoid arthritis, as listed below

Poor prognostic features
  • rheumatoid factor positive
  • anti-CCP antibodies
  • poor functional status at presentation
  • X-ray: early erosions (e.g. after < 2 years)
  • extra articular features e.g. nodules
  • HLA DR4
  • insidious onset


In terms of gender there seems to be a split in what the established sources state is associated with a poor prognosis. However both the American College of Rheumatology and the recent NICE guidelines (which looked at a huge number of prognosis studies) seem to conclude that female gender is associated with a poor prognosis.
+PassMedicine Notes

A number of features have been shown to predict a poor prognosis in patients with rheumatoid arthritis, as listed below

Poor prognostic features
  • rheumatoid factor positive
  • anti-CCP antibodies
  • poor functional status at presentation
  • X-ray: early erosions (e.g. after < 2 years)
  • extra articular features e.g. nodules
  • HLA DR4
  • insidious onset

In terms of gender there seems to be a split in what the established sources state is associated with a poor prognosis. However both the American College of Rheumatology and the recent NICE guidelines (which looked at a huge number of prognosis studies) seem to conclude that female gender is associated with a poor prognosis.



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