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ALL / Nephrology
HIV: renal involvement
HIV: renal involvement
Renal involvement in HIV patients may occur as a consequence of treatment or the virus itself. Protease inhibitors such as indinavir can precipitate intratubular crystal obstruction.HIV-associated nephropathy
HIV-associated nephropathy (HIVAN) accounts for up to 10% of end-stage renal failure cases in the United States. Antiretroviral therapy is the treatment of choice for the disease. If a patient is already taking antiretroviral therapy (which should be all HIV-diagnosed patients) adherence should be checked.
There are five key features of HIVAN:
- massive proteinuria resulting in nephrotic syndrome
- normal or large kidneys
- focal segmental glomerulosclerosis with focal or global capillary collapse on renal biopsy
- elevated urea and creatinine
- normotension
+PassMedicine Notes
Renal involvement in HIV patients may occur as a consequence of treatment or the virus itself. Protease inhibitors such as indinavir can precipitate intratubular crystal obstruction.
HIV-associated nephropathy
HIV-associated nephropathy (HIVAN) accounts for up to 10% of end-stage renal failure cases in the United States. Antiretroviral therapy is the treatment of choice for the disease. If a patient is already taking antiretroviral therapy (which should be all HIV-diagnosed patients) adherence should be checked.
There are five key features of HIVAN:- massive proteinuria resulting in nephrotic syndrome
- normal or large kidneys
- focal segmental glomerulosclerosis with focal or global capillary collapse on renal biopsy
- elevated urea and creatinine
- normotension