Sickle-cell crises: management

Sickle-cell crises: management

• analgesia e.g. opiates
• rehydrate
• oxygen
• consider antibiotics if evidence of infection
• blood transfusion
  • indications include: severe or symptomatic anaemia, pregnancy, pre-operative
  • do not rapidly reduce the percentage of Hb S containing cells
• exchange transfusion
  • indications include: acute vaso-occlusive crisis (stroke, acute chest syndrome, multiorgan failure, splenic sequestration crisis
  • rapidly reduce the percentage of Hb S containing cells
    Exchange transfusions are a way of reducing the number of sickle red cells and increasing the number of normal red cells, in order to improve oxygenation
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    Importance: 86