Pharmacokinetics: excretion

Pharmacokinetics: excretion

• majority of drugs exhibit 'first-order' elimination kinetics i.e. the rate of drug elimination is proportional to drug concentration
  'first-order' elimination kinetics i.e. the rate of drug elimination is proportional to drug concentration
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• certain drugs exhibit zero-order kinetics where the rate of excretion is constant despite changes in plasma concentration
  rate of excretion is constant despite changes in plasma concentration
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  , this is due to saturation of the metabolic process
• examples of drugs exhibiting zero-order kinetics include phenytoin and salicylates
  Drugs which exhibit zero-order kinetics include phenytoin, alcohol and salicylates
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  Importance: 75