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Respiratory physiology

Respiratory physiology

Chloride shift
  • CO2 diffuses into RBCs
  • CO2 + H20 ---- carbonic anhydrase -→ HCO3- + H+
  • H+ combines with Hb
  • HCO3- diffuses out of cell,- Cl- replaces it

Bohr effect
  • increasing acidity (or pCO2) means O2 binds less well to Hb

Haldane effect
  • increase pO2 means CO2 binds less well to Hb
+PassMedicine Notes
Chloride shift
  • CO2 diffuses into RBCs
  • CO2 + H20 ---- carbonic anhydrase ---> HCO3- + H+
  • H+ combines with Hb
  • HCO3- diffuses out of cell,- Cl- replaces it
Bohr effect
  • increasing acidity (or pCO2) means O2 binds less well to Hb
Haldane effect
  • increase pO2 means CO2 binds less well to Hb


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Armando Hasudungan - YouTube
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